Liverpool will be looking to win all their games in the group while AC Milan need a win to have a chance to advance.
The Reds have already confirmed top spot with five group wins, and have also won five in a row across all competitions following a 1-0 win away to Wolves.
AC Milan are third in the group with four points and will go through if they win and Porto fail to pick up three points against Atletico. They have won two in a row after a 2-0 win against Salernitana.
The sides met in the first group game when Liverpool came from behind to get a 3-2 win at Anfield in September.
The hosts will be without Ante Rebic, Davide Calabria, Olivier Giroud, Pietro Pellegri, Simon Kjaer and Samu Castillejo.
Jurgen Klopp is missing Roberto Firmino, Naby Keita, Joe Gomez and Curtis Jones.
Kickoff is at 3 p.m. EST. on Tuesday afternoon at the San Siro. The game will be shown in Canada on DAZN.
Pierre's Footy Talk 